Effect of oxytetracycline on serum response of rainbow trout, Oncorhynchus mykiss
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https://doi.org/10.5281/zenodo.14728175Keywords:
Antibiotics, Immune parameters, Oxytetracycline, Rainbow trout, Yersinia ruckeriAbstract
In this study, the effect of oxytetracycline (OTC), which is widely used in the treatment of fish diseases, on serum response was investigated. We conducted two experiments, the first with intraperitoneal (IP) injection and the second with immersion (IM) bath administration of OTC. For this purpose, fish was injected with IP 20 mg/kg fish weight dose of OTC every day for 4 days. After 24 hours the last treatment serum was collected. In trial second, fish were exposed to 50 mg/L concentration of OTC for 48 hours. The several immune parameters (lysozyme, myeloperoxidase, and total protein activities) and bactericidal activity against Yersinia ruckeri were studied. The present results show that immune parameters (lysozyme, myeloperoxidase and total protein activities) were significantly reduced after injection administration of OTC. However, in the immersion administration of OTC in fish, while the difference in lysosome and total protein activities was not significant, the decrease in myeloperoxidase activities was found to be significant compared to the control group. The serum bactericidal activity of all groups showed a significant increase in comparison with the control untreated group.
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